Dl-NBP (Dl-3-N-Butylphthalide) Treatment Promotes Neurological Functional Recovery Accompanied by the Upregulation of White Matter Integrity and HIF-1α/VEGF/Notch/Dll4 Expression

• Main Authors: Yanping Wang (Author), Yufei Shen (Author), Ziyun Liu (Author), Jingxia Gu (Author), Congying Xu (Author), Shuxia Qian (Author), Xiaoling Zhang (Author), Beiqun Zhou (Author), Yuhua Jin (Author), Yanyun Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dl-3-n-butylphthalide (dl-NBP) was approved by the FDA of China for the treatment of acute ischemic stroke. Dl-NBP has been shown to promote neurological functional recovery and enhance white matter integrity using an endothelin-1-induced focal permanent cerebral ischemia model, which could mimic th...