Characterization of the acetylation of cyclooxygenase-isozymes and targeted lipidomics of eicosanoids in serum and colon cancer cells by the new aspirin formulation IP1867B versus aspirin in vitro

• Main Authors: Ulrika Hofling (Author), Stefania Tacconelli (Author), Annalisa Contursi (Author), Annalisa Bruno (Author), Matteo Mucci (Author), Patrizia Ballerini (Author), Simon Cohen (Author), Paola Patrignani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Aspirin(acetylsalicylic acid, ASA) is recommended for the secondary prevention of atherothrombotic events and has shown anticancer effects. The current enteric-coated drug formulation may reduce aspirin bioavailability. Liquid formulations could improve aspirin pharmacokinetics and pharm...