Loss of MMP-2 in murine osteoblasts upregulates osteopontin and bone sialoprotein expression in a circuit regulating bone homeostasis

• Main Authors: Rebecca A. Mosig (Author), John A. Martignetti (Author)
• Formato: Libro
• Publicado: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

SUMMARY Multicentric osteolysis with arthropathy (MOA; MIM 605156) is an inherited osteolyses and arthritis syndrome resulting from loss of matrix metalloproteinase 2 (MMP-2). We recently demonstrated that Mmp2-/- mice represent a unique model for the study of the human disease, sharing many feature...