Tumour‐derived transforming growth factor‐β signalling contributes to fibrosis in patients with cancer cachexia

• Main Authors: Joanna D.C.C. Lima (Author), Estefania Simoes (Author), Gabriela deCastro (Author), Mychel Raony P.T. Morais (Author), Emidio M. deMatos‐Neto (Author), Michele J. Alves (Author), Nelson I. Pinto (Author), Raquel G. Figueredo (Author), Telma M.T. Zorn (Author), Aloísio S. Felipe‐Silva (Author), Flavio Tokeshi (Author), José P. Otoch (Author), Paulo Alcantara (Author), Fernanda J. Cabral (Author), Emer S. Ferro (Author), Alessandro Laviano (Author), Marilia Seelaender (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro‐environment contributes to systemic inflammation and increased oxidative stress as well as to fibrosis. The aim of the present study was to characterise the inflammatory circulating factors and tu...