Natural product-inspired synthesis of coumarin-chalcone hybrids as potential anti-breast cancer agents

• Main Authors: Nabil A. Alhakamy (Author), Mohammad Saquib (Author), Sanobar (Author), Mohammad Faheem Khan (Author), Waseem Ahmad Ansari (Author), Deema O. Arif (Author), Mohammad Irfan (Author), Mohammad Imran Khan (Author), Mohd Kamil Hussain (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Twelve novel neo-tanshinlactone-chalcone hybrid molecules were constructed through a versatile methodology involving the Horner-Wadsworth-Emmons (HWE) olefination of 4-formyl-2H-benzo [h]chromen-2-ones and phosphonic acid diethyl esters, as the key step, and evaluated for anticancer activity against...