Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses.

• Main Authors: John M Powers (Author), Nicole N Haese (Author), Michael Denton (Author), Takeshi Ando (Author), Craig Kreklywich (Author), Kiley Bonin (Author), Cassilyn E Streblow (Author), Nicholas Kreklywich (Author), Patricia Smith (Author), Rebecca Broeckel (Author), Victor DeFilippis (Author), Thomas E Morrison (Author), Mark T Heise (Author), Daniel N Streblow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mayaro virus (MAYV) is an alphavirus endemic to South and Central America associated with sporadic outbreaks in humans. MAYV infection causes severe joint and muscle pain that can persist for weeks to months. Currently, there are no approved vaccines or therapeutics to prevent MAYV infection or trea...