Design, synthesis and evaluation of novel small molecules acting as Keap1-Nrf2 protein-protein interaction inhibitors

• Main Authors: Yunfeng Sun (Author), Lulu Zheng (Author), Bo Yang (Author), Shuyu Ge (Author), Qiang Li (Author), Mingwan Zhang (Author), Shenghui Shen (Author), Yin Ying (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Direct interference with Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 protein-protein interaction (PPI) has recently been introduced as an attractive approach to control life-threatening diseases like myocarditis. The present study aimed to investigate the potential application in myocarditis of...