A proportion of CD4+ T cells from patients with chronic Chagas disease undergo a dysfunctional process, which is partially reversed by benznidazole treatment.

• Main Authors: Elena Pérez-Antón (Author), Adriana Egui (Author), M Carmen Thomas (Author), Bartolomé Carrilero (Author), Marina Simón (Author), Miguel Ángel López-Ruz (Author), Manuel Segovia (Author), Manuel Carlos López (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Signs of senescence and the late stages of differentiation associated with the more severe forms of Chagas disease have been described in the Trypanosoma cruzi antigen-specific CD4+ T-cell population. However, the mechanisms involved in these functions are not fully kn...