Simulation of the oxidative metabolization pattern of netupitant, an NK1 receptor antagonist, by electrochemistry coupled to mass spectrometry

• Main Authors: Ruxandra Chira (Author), Jens Fangmeyer (Author), Ioan O. Neaga (Author), Valentin Zaharia (Author), Uwe Karst (Author), Ede Bodoki (Author), Radu Oprean (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Considering the frequent use of netupitant in polytherapy, the elucidation of its oxidative metabolization pattern is of major importance. However, there is a lack of published research on the redox behavior of this novel neurokinin-1 receptor antagonist. Therefore, this study was performed to simul...