Photocytotoxicity studies of polyamidoamine (PAMAM) dendrimer and its glucoheptoamidated derivative as delivery drug systems in local PUVA photochemotherapy

• Main Authors: Katarzyna Borowska (Author), Sebastian Radej (Author), Ryszard Galus (Author), Dariusz Śladowski (Author), Wiktor Paskal (Author), Dawid Mehlich (Author), Stanisław Wołowiec (Author)
• Format: Book
• Published: Our Dermatology Online, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

8-methoxypsoralen (8-MOP) given topically in local PUVA photochemotherapy poorly penetrates through the skin to its deeper layers which restricts its effectiveness. Poly(amidoamine) (PAMAM) dendrimers enhanced 8-MOP permeation through the skin. The aim of this study was to investigate photocytotoxic...