Population pharmacokinetic study of benznidazole in pediatric Chagas disease suggests efficacy despite lower plasma concentrations than in adults.

• Main Authors: Jaime Altcheh (Author), Guillermo Moscatelli (Author), Guido Mastrantonio (Author), Samanta Moroni (Author), Norberto Giglio (Author), Maria Elena Marson (Author), Griselda Ballering (Author), Margarita Bisio (Author), Gideon Koren (Author), Facundo García-Bournissen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to long term cardiac morbidity. Treatment of children with benznidazole is effective, but no pediatric pharmacokinetics data are available and clinical pharmacology information on the drug is scarce.Prospective population pharmacokin...