PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

• Main Authors: Vihko Pirkko (Author), Guillot Thomas S (Author), Taylor-Blake Bonnie (Author), Sowa Nathaniel A (Author), Walsh Paul L (Author), Street Sarah E (Author), Wightman R Mark (Author), Zylka Mark J (Author)
• Format: Book
• Published: SAGE Publishing, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main...