Renal carcinoma/kidney progenitor cell chimera organoid as a novel tumorigenesis gene discovery model

• Main Authors: Qi Xu (Author), Sanna Junttila (Author), Andreas Scherer (Author), Khem Raj Giri (Author), Oona Kivelä (Author), Ilya Skovorodkin (Author), Juha Röning (Author), Susan E. Quaggin (Author), Hans-Peter Marti (Author), Jingdong Shan (Author), Anatoly Samoylenko (Author), Seppo J. Vainio (Author)
• Format: Book
• Published: The Company of Biologists, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Three-dimensional (3D) organoids provide a new way to model various diseases, including cancer. We made use of recently developed kidney-organ-primordia tissue-engineering technologies to create novel renal organoids for cancer gene discovery. We then tested whether our novel assays can be used to e...