Use of patient‐derived tumor organoid platform to predict the benefit of postoperative adjuvant chemotherapy for poor responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

• Main Authors: Weisong Xue (Author), Ting Wang (Author), Jiaxin Yao (Author), Wei Wu (Author), Dexin Chen (Author), Botao Yan (Author), Xiaoyu Dong (Author), Yuting Tang (Author), Yunli Zeng (Author), Yueyu He (Author), Peihua Cao (Author), Fangyuan Shao (Author), Wenhua Huang (Author), Chuxia Deng (Author), Jun Yan (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Postoperative adjuvant chemotherapy (AC) for poor responders to neoadjuvant chemoradiotherapy (nCRT) remains debatable among patients with locally advanced rectal cancer (LARC), necessitating biomarkers to accurately predict the benefits of AC. This study aimed to develop a patient‐derived...