Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice

• Príomhchruthaitheoirí: Shahram Saghaei (Údar), Saeid Abbasi Maleki (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Fasa University of Medical Sciences, 2017-12-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.
• Notes: 2228-5105; 2783-1523
• Keywords: coriandrum sativum l; morphine; naloxone; physical dependence; number of jumps; mice; Public aspects of medicine; RA1-1270
• Source: Journal of Advanced Biomedical Sciences, Vol 7, Iss 4, Pp 521-529 (2017)

Background & Objective: Coriandrum sativum L (CS) has different pharmacological properties such as analgesic, anti-inflammatory, and anti-stress effects. Hence, in the present study the effects of CS essential oil on naloxone -induced jumping in morphine-dependent mice was investigated. Material & Methods: In this experimental study, 60 male albino mice were used. The animals were divided into 10 groups of 6, including carrier (10 ml/kg), clonidine (3.5 mg/kg), and different doses of CS essential oil (400, 600, and 800 mg/kg). Tolerance and dependency on morphine were induced by administration of different doses of morphine (50, 50, 75, and 50 mg/kg, respectively) in a 4-day schedule. On the last day, after administration of single dose of morphine, Naloxone (5 mg /kg) was injected and the number of jumps was recorded within 30 minutes. Results: Results showed that all doses of CS essential oil and clonidine, compared to control group, significantly decreased the number of jumping in both tolerance and dependence stage (P<0.001).Also, only high (800mg/kg) and all doses of essential oil reduced the number of jumping during tolerance and dependence stages respectively, better than clonidine . Conclusion: Based on present study findings, it is concluded that, probably the existing linalool in CS could decrease the number of jumps from tolerance and dependence in morphine- dependent mice. Of course, further studies are required to clarify their exact mechanism of action.