Population Pharmacokinetic/Pharmacodynamic Modelling of Daptomycin for Schedule Optimization in Patients with Renal Impairment

• Main Authors: Teresa García-Martínez (Author), María Dolores Bellés-Medall (Author), Maria García-Cremades (Author), Raúl Ferrando-Piqueres (Author), Victor Mangas-Sanjuán (Author), Matilde Merino-Sanjuan (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aims of this study are (i) to develop a population pharmacokinetic/pharmacodynamic model of daptomycin in patients with normal and impaired renal function, and (ii) to establish the optimal dose recommendation of daptomycin in clinical practice. Several structural PK models including linear and...