Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity

• Main Authors: Ebru Koçak Aslan (Author), Muhammed İhsan Han (Author), Vagolu Siva Krishna (Author), Rasoul Tamhaev (Author), Cagatay Dengiz (Author), Şengül Dilem Doğan (Author), Christian Lherbet (Author), Lionel Mourey (Author), Tone Tønjum (Author), Miyase Gözde Gündüz (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB), the most deadly infectious disease worldwide. However, the efficacy of this cornerstone drug has seriously decreased due to emerging INH-resistant strains of <i>Mycobacterium tuberculosis</i> (<...