In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding

Current pharmacological therapy against atrial fibrillation (AF), the most common cardiac arrhythmia, is limited by moderate efficacy and adverse side effects including ventricular proarrhythmia and organ toxicity. One way to circumvent the former is to target ion channels that are predominantly exp...

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Main Authors: Nicholas Ellinwood (Author), Dobromir Dobrev (Author), Stefano Morotti (Author), Eleonora Grandi (Author)
Format: Book
Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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