Antioxidative NAC-Loaded Silk Nanoparticles with Opening Mucosal Tight Junctions for Nasal Drug Delivery: An In Vitro and In Vivo Study

• Main Authors: Tze-Wen Chung (Author), Ting-Ya Wu (Author), Zheng-Yu Siah (Author), Der-Zen Liu (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-06-01T00:00:00Z.
• Fag: article
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Using nasal routes to deliver drugs to the brain using multifunctional nanoparticles (NPs) to bypass the blood-brain barrier (BBB) might enhance the delivery efficacy. Anti-oxidative N-Acetyl-L-cysteine (NAC)-loaded silk fibroin (SF/NAC) NPs are produced, characterized and studied as a potential del...