Possible Interactions of Extracellular Loop IVP2-S6 With Voltage-Sensing Domain III in Cardiac Sodium Channel

• Asıl Yazarlar: Anastasia K. Zaytseva (Yazar), Aleksandr S. Boitsov (Yazar), Anna A. Kostareva (Yazar), Boris S. Zhorov (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Motion transmission from voltage sensors to inactivation gates is an important problem in the general physiology of ion channels. In a cryo-EM structure of channel hNav1.5, residues N1736 and R1739 in the extracellular loop IVP2-S6 approach glutamates E1225 and E1295, respectively, in the voltage-se...