Susceptibility to type 1 diabetes conferred by the <it>PTPN22 </it>C1858T polymorphism in the Spanish population

• Main Authors: Figueredo M Ángeles (Author), Fernández-Arquero Miguel (Author), de la Calle Hermenegildo (Author), Martínez Alfonso (Author), Santiago Jose (Author), de la Concha Emilio G (Author), Urcelay Elena (Author)
• Format: Book
• Published: BMC, 2007-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The protein tyrosine phosphatase N22 gene (<it>PTPN22</it>) encodes a lymphoid-specific phosphatase (LYP) which is an important downregulator of T cell activation. A <it>PTPN22 </it>polymorphism, C1858T, was f...