An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

• Main Authors: Sarah C. Cowles (Author), Allison Sheen (Author), Luciano Santollani (Author), Emi A. Lutz (Author), Brianna M. Lax (Author), Joseph R. Palmeri (Author), Gordon J. Freeman (Author), K. Dane Wittrup (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1 monoclonal antibodies in the clinic, the experimental relationship...