An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

• Hlavní autoři: Sarah C. Cowles (Autor), Allison Sheen (Autor), Luciano Santollani (Autor), Emi A. Lutz (Autor), Brianna M. Lax (Autor), Joseph R. Palmeri (Autor), Gordon J. Freeman (Autor), K. Dane Wittrup (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1 monoclonal antibodies in the clinic, the experimental relationship...