Cardioprotective Effects of Sphingosine-1-Phosphate Receptor Immunomodulator FTY720 in a Clinically Relevant Model of Cardioplegic Arrest and Cardiopulmonary Bypass

• Main Authors: Naseer Ahmed (Author), Adeela Mehmood (Author), Daniele Linardi (Author), Soban Sadiq (Author), Maddalena Tessari (Author), Sultan Ayoub Meo (Author), Rehana Rehman (Author), Waseem M. Hajjar (Author), Nazeer Muhammad (Author), Muhammad Perwaiz Iqbal (Author), Anwar- (Author), Giuseppe Faggian (Author), Alessio Rungatscher (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: FTY720, an immunomodulator derived from sphingosine-1-phosphate, has recently demonstrated its immunomodulatory, anti-inflammatory, anti-oxidant, anti-apoptotic and anti-inflammatory properties. Furthermore, FTY720 might be a key pharmacological target for preconditioning. In this preclin...