Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan

• Үндсэн зохиолчид: Atlal eAbu-Sanad (Зохиогч), Yunzhe eWang (Зохиогч), Fatemeh eHasheminasab (Зохиогч), Justin ePanasci (Зохиогч), Alycia eNoe (Зохиогч), Lorena eRosca (Зохиогч), David eDavidson (Зохиогч), Bahram eSharif-Askari (Зохиогч), Lilian eAmrein (Зохиогч), Raquel eAloyz (Зохиогч), Lawrence ePanasci (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2015-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Enhanced DNA damage repair is one mechanism involved in colon cancer drug resistance. Thus, targeting molecular components of repair pathways with specific small molecule inhibitors may improve the efficacy of chemotherapy. ABT-888 and VE-821, inhibitors of poly-ADP-ribose-polymerase (PARP) and the...