Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan

• Main Authors: Atlal eAbu-Sanad (Author), Yunzhe eWang (Author), Fatemeh eHasheminasab (Author), Justin ePanasci (Author), Alycia eNoe (Author), Lorena eRosca (Author), David eDavidson (Author), Bahram eSharif-Askari (Author), Lilian eAmrein (Author), Raquel eAloyz (Author), Lawrence ePanasci (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enhanced DNA damage repair is one mechanism involved in colon cancer drug resistance. Thus, targeting molecular components of repair pathways with specific small molecule inhibitors may improve the efficacy of chemotherapy. ABT-888 and VE-821, inhibitors of poly-ADP-ribose-polymerase (PARP) and the...