An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy

• Main Authors: Mengru Cai (Author), Tingting Fu (Author), Rongyue Zhu (Author), Panxiang Hu (Author), Jiahui Kong (Author), Shilang Liao (Author), Yuji Du (Author), Yongqiang Zhang (Author), Changhai Qu (Author), Xiaoxv Dong (Author), Xingbin Yin (Author), Jian Ni (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ferroptosis is a recently discovered pathway for regulated cell death pathway. However, its efficacy is affected by limited iron content and intracellular ion homeostasis. Here, we designed a metal-organic framework (MOF)-based nanoplatform that incorporates calcium peroxide (CaO2) and oridonin (ORI...