Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model

• Main Authors: Xiu-Jiang Du (Author), Xing-Jie Peng (Author), Rui-Qi Zhao (Author), Wei-Guang Zhao (Author), Wei-Li Dong (Author), Xing-Hai Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thirty-six novel threoninamide carbamate derivatives were designed and synthesised using active fragment-based pharmacophore model. Antifungal activities of these compounds were tested against Oomycete fungi Phytophthora capsici in vitro and in vivo. Interestingly, compound I-1, I-2, I-3, I-6 and I-...