Effect of Probenecid on Endothelial Cell Growth Rate and Retinal Angiogenesis in an Oxygen-Induced Retinopathy Model

• Main Authors: Jingbo Jiang (Author), Weiming Ou (Author), Xianqiong Luo (Author), Jianwen Xiang (Author), Guosheng Liu (Author), Shuiqing Huang (Author), Hongping Li (Author), Longkai He (Author), Jiamin Gan (Author), Shasha Han (Author), Chuan Nie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Probenecid is an anion transport inhibitor, which, according to the connectivity map (CMap; a biological application database), interferes with hypoxia-induced gene expression changes in retinal vascular endothelial cells (ECs). Here, we investigated the influence of probenecid on retina...