Leveraging Physiologically Based Modelling to Provide Insights on the Absorption of Paliperidone Extended-Release Formulation under Fed and Fasting Conditions

• मुख्य लेखकों: Saima Subhani (लेखक), Viera Lukacova (लेखक), Chaejin Kim (लेखक), Leyanis Rodriguez-Vera (लेखक), Paula Muniz (लेखक), Monica Rodriguez (लेखक), Rodrigo Cristofoletti (लेखक), Sandra Van Os (लेखक), Elena Suarez (लेखक), Stephan Schmidt (लेखक), Valvanera Vozmediano (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Paliperidone was approved by the US FDA in 2006 as an extended-release (ER) tablet (Invega^®) for the once-daily treatment of schizophrenia. This osmotic-controlled release oral delivery system (OROS) offers advantages, such as the prevention of plasma concentration fluctuation...