The novel hyaluronic acid granular hydrogel attenuates osteoarthritis progression by inhibiting the TLR‐2/NF‐κB signaling pathway through suppressing cellular senescence

• Main Authors: Chen Zhang (Author), Zhengxiang Cheng (Author), Yuanyuan Zhou (Author), Ziyi Yu (Author), Hongyu Mai (Author), Changhao Xu (Author), Jing Zhang (Author), Jiali Wang (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In patients with mild osteoarthritis (OA), two to four monthly injections are required for 6 months due to the degradation of hyaluronic acid (HA) by peroxidative cleavage and hyaluronidase. However, frequent injections may lead to local infection and also cause inconvenience to patients du...