Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity

• Main Authors: Jennifer M. Brazill (Author), David Shin (Author), Kristann Magee (Author), Anurag Majumdar (Author), Ivana R. Shen (Author), Valeria Cavalli (Author), Erica L. Scheller (Author)
• Format: Bog
• Udgivet: Elsevier, 2023-02-01T00:00:00Z.
• Fag: article
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Objective: Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when and where mTOR activation mediates these effe...