Discovery of Potent EGFR Inhibitors With 6-Arylureido-4-anilinoquinazoline Derivatives

• Main Authors: Meng Li (Author), Na Xue (Author), Xingang Liu (Author), Qiaoyun Wang (Author), Hongyi Yan (Author), Yifan Liu (Author), Lei Wang (Author), Xiaowei Shi (Author), Deying Cao (Author), Kai Zhang (Author), Yang Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

According to the classical pharmacophore fusion strategy, a series of 6-arylureido-4-anilinoquinazoline derivatives (Compounds 7a-t) were designed, synthesized, and biologically evaluated by the standard CCK-8 method and enzyme inhibition assay. Among the title compounds, Compounds 7a, 7c, 7d, 7f, 7...