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Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine

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An increasing number of antisense oligonucleotides (ASOs) have been approved for clinical use. However, improvements of both efficacy and safety in the central nervous system (CNS) are crucial for the treatment with CNS diseases. We aimed to overcome the crucial issues by our development of various...

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Main Authors: Taiki Matsubayashi (Author), Kotaro Yoshioka (Author), Su Su Lei Mon (Author), Maho Katsuyama (Author), Chunyan Jia (Author), Takao Yamaguchi (Author), Rintaro Iwata Hara (Author), Tetsuya Nagata (Author), Osamu Nakagawa (Author), Satoshi Obika (Author), Takanori Yokota (Author)
Format: Book
Published: Elsevier, 2024-06-01T00:00:00Z.
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3rd Floor Main Library

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