Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrases by chiral N-(biarylsulfonyl)-phosphonic acids

• Autori principali: Grazia Luisi (Autore), Guido Angelini (Autore), Carla Gasbarri (Autore), Antonio Laghezza (Autore), Mariangela Agamennone (Autore), Fulvio Loiodice (Autore), Claudiu T. Supuran (Autore), Cristina Campestre (Autore), Paolo Tortorella (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

A series of nanomolar phosphonate matrix metalloproteinase (MPP) inhibitors was tested for inhibitory activity against a panel of selected human carbonic anhydrase (CA, EC 4.2.1.1) isozymes, covering the cancer-associated CA IX and XII. None of the reported sulfonyl and sulfonylamino-derivatives sen...