Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrases by chiral N-(biarylsulfonyl)-phosphonic acids

• Main Authors: Grazia Luisi (Author), Guido Angelini (Author), Carla Gasbarri (Author), Antonio Laghezza (Author), Mariangela Agamennone (Author), Fulvio Loiodice (Author), Claudiu T. Supuran (Author), Cristina Campestre (Author), Paolo Tortorella (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of nanomolar phosphonate matrix metalloproteinase (MPP) inhibitors was tested for inhibitory activity against a panel of selected human carbonic anhydrase (CA, EC 4.2.1.1) isozymes, covering the cancer-associated CA IX and XII. None of the reported sulfonyl and sulfonylamino-derivatives sen...