Leveraging innovative technology to generate drug response phenotypes for the advancement of biomarker‐driven precision dosing

• Main Authors: Akinyemi Oni‐Orisan (Author), Nithya Srinivas (Author), Krina Mehta (Author), Jesmin Lohy Das (Author), Thu T. Nguyen (Author), Geoffrey H. Tison (Author), Scott R. Bauer (Author), Maria Burian (Author), Ryan S. Funk (Author), Richard A. Graham (Author), Biomarkers and Translational Tools Community Working Group of the American Society for Clinical Pharmacology and Therapeutics (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although traditional approaches to biomarker discovery have elucidated key molecular markers that have improved drug selection (precision medicine), the discovery of biomarkers that inform optimal dose selection (precision dosing) continues to be a challenge in many therapeutic areas. Large...