Personalized‐induced neural stem cell therapy: Generation, transplant, and safety in a large animal model

• Main Authors: Hunter N. Bomba (Author), Kevin T. Sheets (Author), Alain Valdivia (Author), Simon Khagi (Author), Laura Ruterbories (Author), Christopher L. Mariani (Author), Luke B. Borst (Author), Debra A. Tokarz (Author), Shawn D. Hingtgen (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In this study, we take an important step toward clinical translation by generating the first canine‐induced neural stem cells (iNSCs). We explore key aspects of scale‐up, persistence, and safety of personalized iNSC therapy in autologous canine surgery models. iNSCs are a promising new appr...