Increased glycolysis affects β-cell function and identity in aging and diabetes

• Main Authors: Naoya Murao (Author), Norihide Yokoi (Author), Harumi Takahashi (Author), Tomohide Hayami (Author), Yasuhiro Minami (Author), Susumu Seino (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Age is a risk factor for type 2 diabetes (T2D). We aimed to elucidate whether β-cell glucose metabolism is altered with aging and contributes to T2D. Methods: We used senescence-accelerated mice (SAM), C57BL/6J (B6) mice, and ob/ob mice as aging models. As a diabetes model, we used db/db...