The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy

• Main Authors: Nannan Lan (Author), Yongxin Liu (Author), Zhaodong Juan (Author), Rui Zhang (Author), Baoyu Ma (Author), Keliang Xie (Author), Lina Sun (Author), Hao Feng (Author), Meng Sun (Author), Jianfeng Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Perioperative neurocognitive disorders (PND) is a common postoperative neurological complication. Neuroinflammation is a major cause that leads to PND. Autophagy, an intracellular process of lysosomal degradation, plays an important role in the development and maintenance of nervous system. PK11195...