Indoleamine 2,3-dioxygenase controls fungal loads and immunity in Paracoccidioidomicosis but is more important to susceptible than resistant hosts.

• Main Authors: Eliseu F Araújo (Author), Flávio V Loures (Author), Silvia B Bazan (Author), Claudia Feriotti (Author), Adriana Pina (Author), Alessandra S Schanoski (Author), Tânia A Costa (Author), Vera L G Calich (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paracoccidioidomycosis, a primary fungal infection restricted to Latin America, is acquired by inhalation of fungal particles. The immunoregulatory mechanisms that control the severe and mild forms of paracoccidioidomycosis are still unclear. Indoleamine 2,3-dioxygenase (IDO), an IFN-γ induced enzym...