Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy

• Main Authors: Naomi Teramoto (Author), Hidetoshi Sugihara (Author), Keitaro Yamanouchi (Author), Katsuyuki Nakamura (Author), Koichi Kimura (Author), Tomoko Okano (Author), Takanori Shiga (Author), Taku Shirakawa (Author), Masafumi Matsuo (Author), Tetsuya Nagata (Author), Masao Daimon (Author), Takashi Matsuwaki (Author), Masugi Nishihara (Author)
• Format: Book
• Published: The Company of Biologists, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dystrophin, encoded by the DMD gene on the X chromosome, stabilizes the sarcolemma by linking the actin cytoskeleton with the dystrophin-glycoprotein complex (DGC). In-frame mutations in DMD cause a milder form of X-linked muscular dystrophy, called Becker muscular dystrophy (BMD), characterized by...