Calcineurin-NFAT signaling regulates atrogin-1 and MuRF1 via microRNA-23a (miR-23a) during muscle atrophy

• मुख्य लेखकों: Matthew B. Hudson (लेखक), Myra E. Woodworth-Hobbs (लेखक), Jennifer L. Gooch (लेखक), S. Russ Price (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Korean Society of Nephrology, 2012-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Muscle atrophy is prevalent in chronic kidney disease (CKD) patients. MicroRNAs play a critical role in biological processes including muscle atrophy. MicroRNA-23a (miR-23a) negatively regulates the expression of two atrophy-related ubiquitin ligases, atrogin-1 and MuRF1; it is reduced in muscle dur...