HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity

• Главные авторы: Hae Jin Kee (Автор), Eun Hui Bae (Автор), Sangha Park (Автор), Ko Eun Lee (Автор), Sang Heon Suh (Автор), Soo Wan Kim (Автор), Myung Ho Jeong (Автор)
• Формат: ‌
• Опубликовано: Karger Publishers, 2013-07-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Background: Inhibition of histone deacetylase (HDAC) was reported to suppress cardiac hypertrophy and fibrosis in various hypertrophic animal models. However, the HDAC expression profile and HDAC enzyme activity have not yet been investigated in DOCA-salt hypertensive rats. Methods: Unilaterally nep...