HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity

• Main Authors: Hae Jin Kee (Author), Eun Hui Bae (Author), Sangha Park (Author), Ko Eun Lee (Author), Sang Heon Suh (Author), Soo Wan Kim (Author), Myung Ho Jeong (Author)
• Format: Book
• Published: Karger Publishers, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Inhibition of histone deacetylase (HDAC) was reported to suppress cardiac hypertrophy and fibrosis in various hypertrophic animal models. However, the HDAC expression profile and HDAC enzyme activity have not yet been investigated in DOCA-salt hypertensive rats. Methods: Unilaterally nep...