Lysosome activable polymeric vorinostat encapsulating PD-L1KD for a combination of HDACi and immunotherapy

• Main Authors: Fengkun Lu (Author), Lei Hou (Author), Sizhen Wang (Author), Yingjie Yu (Author), Yunchang Zhang (Author), Linhong Sun (Author), Chen Wang (Author), Zhiqiang Ma (Author), Feng Yang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PD-1/PD-L1 blocking therapy has become one of the most promising methods in the field of tumor treatment. However, it encounters the challenge of immune escape due to the exhaustion of T cells. Studies have shown that the epigenetic regulation drug histone deacetylase inhibitor (HDACi) may be able t...