Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms

• Main Authors: Haiyang Li (Author), Wenjian Jiang (Author), Weihong Ren (Author), Dong Guo (Author), Jialong Guo (Author), Xiaolong Wang (Author), Yuyong Liu (Author), Feng Lan (Author), Jie Du (Author), Hongjia Zhang (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous studies indicate that extracellular matrix (ECM) disorders lead to the apoptosis of Vascular Smooth Muscle Cells (VSMCs), which impairs the aortic wall by reducing the generation of elastic fibers, and ultimately result in ascending aortic aneurysm. The critical role of the Yes-associated p...