RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade

• Main Authors: Ziwei Lv (Author), Yuanyuan Ren (Author), Yang Li (Author), Fanglin Niu (Author), Zhuozhuo Li (Author), Man Li (Author), Xiaofang Li (Author), Qinhua Li (Author), Deqing Huang (Author), Yi Yu (Author), Yuyan Xiong (Author), Lu Qian (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Obesity is well-established as a significant contributor to the development of insulin resistance (IR) and diabetes, partially due to elevated plasma saturated free fatty acids like palmitic acid (PA). Grb10-interacting GYF Protein 2 (GIGYF2), an RNA-binding protein, is widely ex...