Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis

• Main Authors: Takashi Hashimoto (Author), Kent Sakai (Author), Kristen M. Sanders (Author), Gil Yosipovitch (Author), Tasuku Akiyama (Author)
• Formato: Livro
• Publicado em: Medical Journals Sweden, 2019-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The Janus kinase 1/3 inhibitor tofacitinib has demonstrated an antipruritic effect in two phase III studies in psoriasis. However, the mechanisms behind this antipruritic effect are still unknown. We presently investigated whether tofacitinib affects spontaneous itch as well as expression of itch-re...