Targeting Hypoxia-Inducible Factor-1α in Pancreatic Cancer: siRNA Delivery Using Hyaluronic Acid-Displaying Nanoparticles

• Main Authors: Alice Spadea (Author), Annalisa Tirella (Author), Julio Manuel Rios de la Rosa (Author), Enrique Lallana (Author), Manal Mehibel (Author), Brian Telfer (Author), Nicola Tirelli (Author), Margaret Jayne Lawrence (Author), Kaye J. Williams (Author), Ian J. Stratford (Author), Marianne Ashford (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background/Objectives:</b> Conventional anticancer therapies often lack specificity, targeting both cancerous and normal cells, which reduces efficacy and leads to undesired off-target effects. An additional challenge is the presence of hypoxic regions in tumors, where the Hypoxia Ind...