HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies

• Main Authors: Haneen Amawi (Author), Noor A. Hussein (Author), Chandrabose Karthikeyan (Author), Elangovan Manivannan (Author), Alexander Wisner (Author), Frederick E. Williams (Author), Temesgen Samuel (Author), Piyush Trivedi (Author), Charles R. Ashby (Author), Amit K. Tiwari (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was designed to determine the in vitro mechanisms by which the novel silybin derivative, (E)-3-(3-(benzyloxy) phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (HM015k or 15k), produces its anticancer efficacy in ovarian cancer cells. Compound 15k induced apoptosis in ovarian cancer cells in a t...