Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies

• Главные авторы: Gui-Qing Xu (Автор), Xiao-Qing Gong (Автор), Ying-Ying Zhu (Автор), Xiao-Jun Yao (Автор), Li-Zeng Peng (Автор), Ge Sun (Автор), Jian-Xue Yang (Автор), Long-Fei Mao (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Предметы: article
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Indoleamine 2,3-dioxygenase 1 (IDO1) plays a predominant role in cancer immunotherapy which catalyzes the initial and rate limiting steps of the kynurenine pathway as a key enzyme. To explore novel IDO1 inhibitors, five derivatives of erlotinib-linked 1,2,3-triazole compounds were designed by using...