Discovery of a CCR2-targeting pepducin therapy for chronic pain

• Main Authors: Élora Midavaine (Author), Rebecca L. Brouillette (Author), Elizabeth Théberge (Author), Christine E. Mona (Author), Sakeen W. Kashem (Author), Jérôme Côté (Author), Vera Zeugin (Author), Élie Besserer-Offroy (Author), Jean-Michel Longpré (Author), Éric Marsault (Author), Philippe Sarret (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting the CCL2/CCR2 chemokine axis has been shown to be effective at relieving pain in rodent models of inflammatory and neuropathic pain, therefore representing a promising avenue for the development of non-opioid analgesics. However, clinical trials targeting this receptor for inflammatory con...